The perfectly preserved mummy had lain forgotten in the museum basement for years. Hoping to infuse Boston's Crispin Museum with much needed financial aid, "Madam X" is examined by medical examiner Maura Isles. She soon discovers that the mummy is not an ancient egyptian artifact but instead a modern day murder victim. Discovering other mummies, Maura and Detective Jane Rizzoli, race against the clock as they fnd more cryptic messages. When archaeologist Josephine Pulcillo goes missing, Jane and Maura have little time before more artifacts are added to the killers collection.