The Sculptor by Scott McCloud is possibly one of the most original plot/storyline I've come across thus far.
David is a desperate, unlucky sculptor who happens to come across Death. They strike up a deal: David can make anything he wants out of anything in his environment with his talented hands. Oh yeah by the way he has 200 days left to live.
A little slow getting in, but once you're in and the countdown begins on David's impending death it gets better and better. On the artwork alone I give five stars as well, but the story and everything I felt was unique